A review of the literature was conducted using the search engines Web of Science, Pubmed, Scopus, and Google Scholar. The present review aims to compare the properties (proliferation, migration, clonogenicity, angiogenic capacity, differentiation potential, and secretome) of MSCs derived from bone marrow, adipose tissue, and dental tissue to enable clinicians to select the best source of MSCs for their clinical application in bone and oral tissue regeneration to delineate new translational perspectives. In this sense, for bone, dental, and oral injuries, MSCs could provide an innovative and effective therapy. Mesenchymal stem cells (MSCs) can be obtained from several sources, including bone marrow and adipose tissue, already used in orthopedic regenerative applications. Thus, optimal source selection should harmonize this complex setting and ensure a well-personalized and effective treatment. Indeed, the source conditions, the quality and quantity of MSCs, have an influence on the growth factors, cytokines, extracellular vesicles, and secrete bioactive factors of the regenerative milieu, thus influencing the clinical result.
The success of regenerative medicine in various clinical applications depends on the appropriate selection of the source of mesenchymal stem cells (MSCs).
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To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them. PDF is the official format for papers published in both, html and pdf forms.You may sign up for e-mail alerts to receive table of contents of newly released issues.Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.Insights into the roles of Notch in cells of the tumor environment and the impact on tumor-stroma interactions will lead to a deeper understanding of Notch signaling in cancer and inspire new strategies for Notch-based tumor therapy. In this review, we discuss how aberrant Notch signaling can affect three types of cells in the tumor stroma-cancer-associated fibroblasts, immune cells and vascular cells-and how this influences their interactions with the tumor cells.
The Notch signaling pathway is an architecturally simple signaling mechanism, well known for its role in cell fate regulation during organ development and in tissue homeostasis.
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